Metals Advances ›› 2026, Vol. 39: 47-67.DOI: 10.1016/j.metadv.2025.12.005

• Review Article • Previous Articles     Next Articles

A review on the biomedical Ti-Cu alloys: Design, preparation, microstructure and properties

Kunmao Lia, Shengfeng Zhoub,*(), Jing Liua,**(), Feng Yanga, Chengliang Yangc,d,***()   

  1. a School of Materials and Architectural Engineering, Guizhou Normal University, Guiyang 550025, China
    b Institute of Advanced Wear & Corrosion Resistance and Functional Materials, Jinan University, Guangzhou 510632, China
    c Department of Orthopedics, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi 533000, China
    d Guangxi Key Laboratory for Biomedical Materials Research, , Guangxi 533000, China
  • Received:2025-08-16 Revised:2025-09-14 Accepted:2025-09-23 Online:2026-01-10 Published:2026-03-10
  • Contact: *Institute of Advanced Wear & Corrosion Resistance and Functional Materials, Jinan University, Guangzhou 510632, Guangdong, China. E-mail addresses: zhousf1228@163.com (S. Zhou), **408452347@qq.com (J. Liu), ***yangchengliang@ymcn.edu.cn (C. Yang).

Abstract:

In clinical fields with a high risk of infection, such as orthopedics and dentistry, stringent requirements are imposed on the mechanical properties, biocompatibility, and antibacterial performance of biomedical materials. As an emerging functional biomedical alloy, Titanium-copper (Ti-Cu) alloys have received increasing attention due to their unique composition and microstructure, which endow these materials with favorable mechanical strength, biological activity, and long-lasting antibacterial functionality. However, a systematic summary of the existing research findings remains lacking. In this review, the classification and fundamental properties of Ti-Cu alloys are first outlined. Recent progress in design strategies, fabrication techniques, microstructural characteristics, mechanical behavior, wear resistance, corrosion performance, and biological properties is comprehensively reviewed. Special emphasis is placed on the dual forms of Cu (solid solution Cu and Ti2Cu phase) and their synergistic effects on both mechanical and biological performance. The antibacterial mechanisms and biosafety of Cu are specifically summarized, and its antibacterial efficacy and tissue compatibility are evaluated based on in vitro studies and animal models. Based on these findings, the key challenges associated with the practical application of Ti-Cu alloys are analyzed, and potential directions for optimization and future development are proposed. The review concludes with a concise summary and several forward-looking perspectives.

Key words: Biomedical material, Ti-Cu alloys, Microstructure, Processing, Antibacterial properties