Superparamagnetic CoFe2O4@Au with High Specific Absorption Rate and Intrinsic Loss Power for Magnetic Fluid Hyperthermia Applications

doi:10.1007/s40195-018-0830-5

Abstract

Abstract:

CoFe₂O₄ nanoparticles (NPs) and surface modified with gold (Au) have been synthesized by a thermal decomposition method. The obtained NPs and formation of CoFe₂O₄@Au core-shell (CS) were confirmed by characterizing their structural and optical properties using X-ray powder diffraction (XRD) patterns, Fourier transform infrared spectroscopy, Raman spectroscopy, UV-Visible and photoluminescence studies. Morphological and compositional studies were carried out using high-resolution transmission electron microscopy and energy-dispersive X-ray spectroscopy, while the magnetic properties were determined using alternating gradient magnetometer and Mossbauer to define the magneto-structural effects of shell formation on the core NPs. Induction heating properties of CoFe₂O₄ and CoFe₂O₄@Au CS magnetic nanoparticles (MNPs) have been investigated and correlated with magneto-structural properties. Specific absorption rate and intrinsic loss power were calculated for these MNPs within the human tolerable range of frequency and amplitude, suggesting their potential in magnetic fluid hyperthermia therapy for possible cancer treatment.

Key words: CoFe₂O₄@Au, Superparamagnetic, Specific, absorption, rate, (SAR), Intrinsic, loss, power, (ILP), Magnetic, fluid, hyperthermia

Sandip Sabale, Vidhya Jadhav, Shubhangi Mane-Gavade, Xiao-Ying Yu. Superparamagnetic CoFe₂O₄@Au with High Specific Absorption Rate and Intrinsic Loss Power for Magnetic Fluid Hyperthermia Applications[J]. Acta Metallurgica Sinica (English Letters), 2019, 32(6): 719-725.

Figures/Tables 5

Fig. 1 Structural, optical and magnetic properties of CoFe2O4NPs (red) and CoFe2O4@Au CSs (blue) NPs. X-ray diffraction pattern a (filled blue circles and red square showing the representative peaks for Au and CoFe2O4 in core-shell pattern); infrared absorption spectra b; Raman spectra showing the Raman active bands excited at 488 nm c; room temperature M-H curves d (the inset shows the CoFe2O4@Au CSs suspension before a, after b an external magnetic field)

Table 1 Summary of the crystallite size from XRD (DXRD), TEM diameter (DTEM), saturation magnetization (MS), coercivity (HC), composition from EDS analysis, average isomer shift (IS) and internal hyperfine field (Hf) from Mossbauer analysis of obtained MNPs

Sample	D_XRD (nm)	D_TEM (nm)	M_S (emu g^-1)	H_C (Oe)	Composition (wt%)				I_S (mm s^-1)	H_f (mm s^-1)
Sample	D_XRD (nm)	D_TEM (nm)	M_S (emu g^-1)	H_C (Oe)	O	Fe	Co	Au	I_S (mm s^-1)	H_f (mm s^-1)
CoFe₂O₄	4.8?±?0.83	4.50?±?0.5	42.59	7.65	21.87	50.75	27.37	-	0.373?±?0.041	31.6?±?1.40
CoFe₂O₄@Au	5.9?±?0.35	5.10?±?0.5	33.02	0.0	21.18	41.77	22.74	14.31	0.328?±?0.028	26.6?±?1.10

Fig. 2 Mossbauer spectra recorded at room temperature of CoFe2O4 NPs a and CoFe2O4@Au CSs b, (sphere points showing the recorded data points and the gray area showing the distribution of hyperfine field fit using NORMOS/DIST program); representative HRTEM micrographs of CoFe2O4NPs c, d, CoFe2O4@Au CSs e, f

Fig. 3 Temperature-time curves of a 5 mg mL-1; b 10 mg mL-1 CoFe2O4 MNPs; c 5 mg mL-1; d 10 mg mL-1 CoFe2O4@Au CS at different applied AC magnetic fields (dotted line showing the threshold hyperthermia temperature at respective time in s)

Table 2 Calculated rise in temperature (ΔT, °C), specific absorption rate (SAR, W g-1) and intrinsic loss power (ILP, nHm2 kg-1) of CoFe2O4 NPs and CoFe2O4@Au CSs NPs

Applied field (H)?→?		13.3 (kA m^-1)			20.0 (kA m^-1)			26.7 (kA m^-1)
Sample	Conc. (mg mL)	ΔT	SAR	ILP	ΔT	SAR	ILP	ΔT	SAR	ILP
CoFe₂O₄	5	12.16	32.81	0.67	20.88	54.26	0.49	25.89	68.85	0.35
CoFe₂O₄	10	14.83	17.89	0.37	26.65	38.82	0.35	35.43	53.76	0.27
CoFe₂O₄@Au	5	14.88	33.38	0.68	20.08	40.32	0.37	27.94	54.97	0.28
CoFe₂O₄@Au	10	21.00	16.91	0.35	26.47	21.21	0.19	31.10	26.64	0.14

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Superparamagnetic CoFe₂O₄@Au with High Specific Absorption Rate and Intrinsic Loss Power for Magnetic Fluid Hyperthermia Applications

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