In this paper, a bionic method was presented to improve the erosion resistance of blade of the centrifugal fan. A numerical investigation of the solid particle erosion on the standard and bionic configuration blade of 4–72No 10C centrifugal fan was presented. The numerical study employs computational fluid dynamics (CFD) software, based on a finite volume method, in which the discrete phase model was used to modele the solid particles flow, and the Eulerian conservation equation was adopt to simulate the continuous phase. Moreover, user-defined function was used to define wear equation. The various diameters of the particles were taken into account. The positions of collision of standard and bionic fan blades were discussed, and two kinds of centrifugal fan blade wear were compared. The results show that the particles from the incident source with different positions have different processes of turning and movement when enter into the impeller. The trajectories of flow in the fan channel are significantly different for the particles with different diameters. Bionic fan blade have lower erosion rate than the standard fan blade when the particle size is 20 μm. The anti-erosion mechanism of the bionic fan blade was discussed.